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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG1 All Species: 31.82
Human Site: S313 Identified Species: 63.64
UniProt: P18858 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18858 NP_000225.1 919 101736 S313 L R M V E T L S N L L R S V V
Chimpanzee Pan troglodytes XP_524321 919 101662 S313 L R M V E T L S N L L R S V V
Rhesus Macaque Macaca mulatta XP_001111346 919 101454 S313 L R M V E T L S N L L R S V V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P37913 916 102271 S311 L K M V E T L S N L L R S V V
Rat Rattus norvegicus Q9JHY8 918 102463 S313 L K M V E T L S N L L R S V V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis P51892 1070 120215 S466 L K N V E T L S N F L R S V I
Zebra Danio Brachydanio rerio NP_001119860 1058 118776 S455 L K N I E T L S N F L R S V I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W1H4 747 84700 T190 L E L G V A E T T L M K A I C
Honey Bee Apis mellifera XP_392286 861 97795 E290 A P A Y E G I E L G V A E T N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001180844 967 108403 S364 L K T I E I L S D F L T S V M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42572 790 87722 V233 I A P A H E G V E L G I G E S
Baker's Yeast Sacchar. cerevisiae P04819 755 84810 G198 Y L F I N R L G P D Y E A G L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 98.2 N.A. N.A. 84 81.3 N.A. N.A. N.A. 56.9 56.1 N.A. 44 46 N.A. 48.5
Protein Similarity: 100 99.4 98.8 N.A. N.A. 89.3 87.8 N.A. N.A. N.A. 71.1 68.6 N.A. 60.2 65.7 N.A. 66.2
P-Site Identity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. N.A. N.A. 73.3 66.6 N.A. 13.3 6.6 N.A. 46.6
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. N.A. N.A. 86.6 86.6 N.A. 53.3 20 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. 40.3 36 N.A.
Protein Similarity: N.A. N.A. N.A. 58.3 53.6 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 9 9 0 9 0 0 0 0 0 9 17 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 0 0 0 0 0 0 0 0 9 9 0 0 0 0 0 % D
% Glu: 0 9 0 0 75 9 9 9 9 0 0 9 9 9 0 % E
% Phe: 0 0 9 0 0 0 0 0 0 25 0 0 0 0 0 % F
% Gly: 0 0 0 9 0 9 9 9 0 9 9 0 9 9 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 25 0 9 9 0 0 0 0 9 0 9 17 % I
% Lys: 0 42 0 0 0 0 0 0 0 0 0 9 0 0 0 % K
% Leu: 75 9 9 0 0 0 75 0 9 59 67 0 0 0 9 % L
% Met: 0 0 42 0 0 0 0 0 0 0 9 0 0 0 9 % M
% Asn: 0 0 17 0 9 0 0 0 59 0 0 0 0 0 9 % N
% Pro: 0 9 9 0 0 0 0 0 9 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 25 0 0 0 9 0 0 0 0 0 59 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 67 0 0 0 0 67 0 9 % S
% Thr: 0 0 9 0 0 59 0 9 9 0 0 9 0 9 0 % T
% Val: 0 0 0 50 9 0 0 9 0 0 9 0 0 67 42 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 9 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _